The Pollutant Organotins Leads to Respiratory Disease by Inflammation: A Mini-Review
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چکیده
منابع مشابه
The Pollutant Organotins Leads to Respiratory Disease by Inflammation: A Mini-Review
Organotins (OTs) are organometallic pollutants. The OTs are organometallic pollutants that are used in many industrial, agricultural, and domestic products, and it works as powerful biocidal compound against large types of microorganisms such as fungi and bacteria. In addition, OTs are well known to be endocrine-disrupting chemicals, leading abnormalities an "imposex" phenomenon in the female m...
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プロスタノイ ドは通常は細胞内に貯蔵されてお らず,細 胞内で必要 に応 じて合成,放 出され,そ の局所で多彩な作用 を発揮 し,生 体 のホメオスタ シスの維持 に関わる重要なオータコイドである. なかでも,生 体内において もっとも豊富に存在す るプ ロスタノイ ドであ るプロスタ グラ ンジン (PG)E2の 生理活性は血管拡張,胃 液分泌抑制,子 宮収縮,気 管支拡張,発 熱や発痛,炎 症反応など 多岐にわたっている.PGE2生 合成経路 はつぎの ような複数の酵素を介 した反応系で説明されてい る.す なわち,細 胞が生理的,病 理的なさまざま な刺激を受 けると,ホ スホ リパーゼA2(PLA2)に より生体膜 リン脂質からアラキドン酸が遊離され たあと,こ のアラキドン酸がシクロオキシゲナー ゼ(COX)に よりPGH,に 変換 される.さ らに,こ のPGH2がPG...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2018
ISSN: 1664-2392
DOI: 10.3389/fendo.2017.00369